Publications

Publications

Alexander Gerbershagen

1	SND@LHC: the scattering and neutrino detector at the LHC The SND@LHC Collaboration, Acampora, G., Ahdida, C., Albanese, R., Albrecht, C., Alexandrov, A., Andreini, M., Anokhina, A., Asada, T., Auberson, N., Baldanza, C., Battilana, C., Bernard, F., Bestmann, P., Betancourt, C., Blanco, A., Bogomilov, M., Bonacorsi, D., Bonivento, W. M. & Bordalo, P. & 33 others, , 23-May-2024, In: Journal of Instrumentation. 19, 5, 56 p., P05067.
2	Magnetic Design of a Compact GaToroid for Very High Energy Electron and Pre-Clinical Hadron Beams Bottura, L., Haziot, A., Latina, A., Both, S., Gerbershagen, A., Butler, C., Dosanjh, M., Leadley, S. & Robertson, C., 1-Aug-2024, In: IEEE Transactions on Applied Superconductivity. 34, 5, 5 p., 4403005.
3	High Intensity Kaon Experiments (HIKE) at CERN SPS for the HIKE Collaboration & Fiorenza, R., 2024, In: Nuovo Cimento della Societa Italiana di Fisica C. 47, 3, 86.
4	Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates Bateman, J. J., Buchanan, E., Corsini, R., Farabolini, W., Korysko, P., Garbrecht Larsen, R., Malyzhenkov, A., Ortega Ruiz, I., Rieker, V., Gerbershagen, A. & Dosanjh, M., 3-Apr-2024, In: Physics in Medicine and Biology. 69, 8, 17 p., 085006.
5	Development of a New Electromagnetic Extraction Channel from the AGOR Cyclotron Kremers, H. R., Jones, B. N., Smit, H. A. J., Gerbershagen, A. & Brandenburg, S., 2024, In: Journal of Physics: Conference Series. 2687, 6 p., 082012.

Marco Schippers

1	Physics and accelerators for particle therapy Schippers, J. M., 28-nov.-2024, Proceedings of the Joint Universities Accelerator School (JUAS): Courses and exercises. Métral, E. (uitgave). Geneva: CERN, blz. 1841-1852 12 blz. (CERN Yellow Reports: School Proceedings; vol. 3).

Peter Dendooven

1	RayStation/GATE Monte Carlo simulation framework for verification of proton therapy based on the12N imaging Ahmadi Ganjeh, Z., Zapien-Campos, B., Traneus, E., Both, S. & Dendooven, P., 27-Sept-2024, In: Physics in Medicine and Biology. 69, 19, 15 p., 195007.
2	Measurement of the12C(p,n)12N reaction cross section below 150 MeV Zapien Campos, B., Ahmadi Ganjeh, Z., Both, S. & Dendooven, P., 7-Apr-2024, In: Physics in Medicine and Biology. 69, 7, 20 p., 075025.
3	Gamma-ray sources imaging and test-beam results with MACACO III Compton camera Barrientos, L., Borja-Lloret, M., Casaña, J. V., Dendooven, P., García López, J., Hueso-González, F., Jiménez-Ramos, M. C., Pérez-Curbelo, J., Ros, A., Roser, J., Senra, C., Viegas, R. & Llosá, G., Jan-2024, In: Physica Medica. 117, 10 p., 103199.

Sytze Brandenburg

1	Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS) Radstake, W. E., Parisi, A., Miranda, S., Gautam, K., Vermeesen, R., Rehnberg, E., Tabury, K., Coppes, R., van Goethem, M.-J., Brandenburg, S., Weber, U., Fournier, C., Durante, M., Baselet, B. & Baatout, S., 6-May-2024, In: Scientific Reports. 14, 1, 15 p., 10400.
2	Development of a New Electromagnetic Extraction Channel from the AGOR Cyclotron Kremers, H. R., Jones, B. N., Smit, H. A. J., Gerbershagen, A. & Brandenburg, S., 2024, In: Journal of Physics: Conference Series. 2687, 6 p., 082012.
3	A simulation framework for preclinical proton irradiation workflow Malimban, J., Ludwig, F., Lathouwers, D., Staring, M., Verhaegen, F. & Brandenburg, S., 4-Nov-2024, In: Physics in Medicine and Biology. 69, 21, 19 p., 215040.

Julia Even

1	Ion-optical simulations for the NEXT solenoid separator Soylu, A., Chen, X., Even, J., Karpov, A., Saiko, V., Sarén, J. & Uusitalo, J., Oct-2024, In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 1067, 8 p., 169674.

Lara Barazzuol

1	Evaluating and reporting LET and RBE-weighted dose in proton therapy for glioma - The Dutch approach. Dirk Wagenaar, Steven J M Habraken, Ilaria Rinaldi, Daniëlle B P Eekers, Miranda Kramer, Jaap P M Jaspers, Dik van Gent , Lara Barazzuol, Yvonne L B Klaver, Jaap Zindler, Ida Coremans, Inge Compter , Daniel Scandurra, Hiska L van der Weide, Stefan Both, Mischa Hoogeman, Mirko Unipan, Alejandra Méndez Romero. Radiother. Oncol. 2024 Nov 25:110653. DOI: 10.1016/j.radonc.2024.110653.
2	Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production van Rijn-Dekker, M. I., la Bastide-van Gemert, S., Stokman, M. A., Vissink, A., Coppes, R. P., Langendijk, J. A., van Luijk, P. & Steenbakkers, R. J. H. M., 1-Nov-2024, In: International Journal of Radiation Oncology, Biology, Physics. 120, 3, p. 772-782 11 p.
3	Proton therapy induces a local microglial neuroimmune response Voshart, D. C., Klaver, M., Jiang, Y., van Weering, H. R. J., van Buuren-Broek, F., van der Linden, G. P., Cinat, D., Kiewiet, H. H., Malimban, J., Vazquez-Matias, D. A., Reali Nazario, L., Scholma, A. C., Sewdihal, J., van Goethem, M.-J., van Luijk, P., Coppes, R. P. & Barazzuol, L., Apr-2024, In: Radiotherapy and Oncology. 193, 8 p., 110117.
4	Physics Considerations for Evaluation of Dose for Dose-Response Models of Pediatric Late Effects From Radiation Therapy Olch, A. J., van Luijk, P., Hua, C. H., Avanzo, M., Howell, R. M., Yorke, E., Aznar, M. C. & Kry, S. F., 1-Jun-2024, In: International Journal of Radiation Oncology Biology Physics. 119, 2, p. 360-368 9 p.
5	Clinical Introduction of Stem Cell Sparing Radiotherapy to Reduce the Risk of Xerostomia in Patients with Head and Neck Cancer van Rijn-Dekker, M. I., van der Schaaf, A., Nienhuis, S. W., Arents-Huls, A. S., Ger, R. B., Hamming-Vrieze, O., Hoebers, F. J. P., de Ridder, M., Vigorito, S., Zwijnenburg, E. M., Langendijk, J. A., van Luijk, P. & Steenbakkers, R. J. H. M., 23-Dec-2024, In: Cancers. 16, 24, 14 p., 4283.
6	Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study Beukema, J. C., Haveman, J.-W., Langendijk, J. A., Oldehinkel, E., van den Bergh, A. C. M., de Haan, J. J., van Melle, J. P., van Luijk, P. & Muijs, C. T., Nov-2024, In: Radiotherapy and Oncology. 200, 7 p., 110479.

Peter van Luijk

1	Salivary and Dental Complications in Childhood Cancer Survivors Treated With Radiation Therapy to the Head and Neck: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) Comprehensive Review Milgrom, S. A., van Luijk, P., Pino, R., Ronckers, C. M., Kremer, L. C., Gidley, P. W., Grosshans, D. R., Laskar, S., Okcu, M. F., Constine, L. S. & Paulino, A. C., 1-Jun-2024, In: International Journal of Radiation Oncology, Biology, Physics. 119, 2, p. 467-481 15 p.
2	Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production van Rijn-Dekker, M. I., la Bastide-van Gemert, S., Stokman, M. A., Vissink, A., Coppes, R. P., Langendijk, J. A., van Luijk, P. & Steenbakkers, R. J. H. M., 1-Nov-2024, In: International Journal of Radiation Oncology, Biology, Physics. 120, 3, p. 772-782 11 p.
3	Proton therapy induces a local microglial neuroimmune response Voshart, D. C., Klaver, M., Jiang, Y., van Weering, H. R. J., van Buuren-Broek, F., van der Linden, G. P., Cinat, D., Kiewiet, H. H., Malimban, J., Vazquez-Matias, D. A., Reali Nazario, L., Scholma, A. C., Sewdihal, J., van Goethem, M.-J., van Luijk, P., Coppes, R. P. & Barazzuol, L., Apr-2024, In: Radiotherapy and Oncology. 193, 8 p., 110117.
4	Physics Considerations for Evaluation of Dose for Dose-Response Models of Pediatric Late Effects From Radiation Therapy Olch, A. J., van Luijk, P., Hua, C. H., Avanzo, M., Howell, R. M., Yorke, E., Aznar, M. C. & Kry, S. F., 1-Jun-2024, In: International Journal of Radiation Oncology Biology Physics. 119, 2, p. 360-368 9 p.
5	Clinical Introduction of Stem Cell Sparing Radiotherapy to Reduce the Risk of Xerostomia in Patients with Head and Neck Cancer van Rijn-Dekker, M. I., van der Schaaf, A., Nienhuis, S. W., Arents-Huls, A. S., Ger, R. B., Hamming-Vrieze, O., Hoebers, F. J. P., de Ridder, M., Vigorito, S., Zwijnenburg, E. M., Langendijk, J. A., van Luijk, P. & Steenbakkers, R. J. H. M., 23-Dec-2024, In: Cancers. 16, 24, 14 p., 4283.
6	Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: A prospective cohort study Beukema, J. C., Haveman, J.-W., Langendijk, J. A., Oldehinkel, E., van den Bergh, A. C. M., de Haan, J. J., van Melle, J. P., van Luijk, P. & Muijs, C. T., Nov-2024, In: Radiotherapy and Oncology. 200, 7 p., 110479.

Rob Coppes

1	Driving innovation in radiation oncology in a changing world: the Green Journal's roadmap for the next decade. Blanchard P, Georg D, Coppes RP, Vrou Offersen B. Radiation Oncology 2024 Oct 9:110586. DOI: 10.1016/j.radonc.2024.110586.
2	Future of Team-based Basic and Translational Science in Radiation Oncology. Coppes RP, van Dijk LV. Semin. Radiat. Oncol. 2024 Oct;34(4):370-378. DOI: 10.1016/j.semradonc.2024.07.007.
3	Pursuing New Horizons With New Collaborators: This Is the Future of Radiation Oncology. Jaffray DA, Coppes RP, McNair H, Viswanathan A. Semin. Radiat .Oncol. 2024 Oct;34(4):367-369. DOI: 10.1016/j.semradonc.2024.08.002.
4	Sparing of the heart facilitates recovery from cardiopulmonary side effects after thoracic irradiation. Wiedemann J, Paruchuru SK, den Boef LE, Brouwer U, Silljé HHW, Schouten EM, Dickinson MG, van Goethem MJ, Coppes RP, van Luijk P. Int J Radiat Oncol Biol Phys. 2024 Aug 14:S0360-3016(24)03178-X. DOI: 10.1016/j.ijrobp.2024.07.2330.
5	Organoid-based personalized medicine: from tumor outcome prediction to autologous transplantation. Soto-Gamez A, Gunawan JP, Barazzuol L, Pringle S, Coppes RP. Stem cells 2024 Jun 14;42(6):499-508. DOI: 10.1093/stmcls/sxae023.
6	MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer. Metman MJH, Jonker PKC, Sondorp LHJ, van Hemel BM, Sywak MS, Gill AJ, Jansen L, van Diest PJ, van Ginhoven TM, Löwik CWGM, Nguyen AH, Robinson DJ, van Dam GM, Links TP, Coppes RP, Fehrmann RSN, Kruijff S. Eur J Nucl Med Mol Imaging 2024 Jul;51(8):2384-2394. DOI: 10.1007/s00259-023-06525-5.
7	Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms. Chen D, Zhao C, Zhang J, Knol CWJ, Osipyan A, Majerníková N, Chen T, Xiao Z, Adriana J, Griffith AJ, Gamez AS, van der Wouden PE, Coppes RP, Dolga AM, Haisma HJ, Dekker FJ. Advamced Science 2024 Jun 25:e2403963. DOI: 10.1002/advs.202403963.
8	Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production. van Rijn-Dekker MI, la Bastide-van Gemert S, Stokman MA, Vissink A, Coppes RP, Langendijk JA, van Luijk P, Steenbakkers RJHM. International Journal of Radiation Oncology 2024 Int J Radiat Oncol Biol Phys. 2024 Nov 1;120(3):772-782. DOI: 10.1016/j.ijrobp.2024.04.012.
9	Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer. Zanten JV, Jorritsma-Smit A, Westra H, Baanstra M, Bruin-Jellema A, Allersma D, Gareb B, Coppes RP. Pharmaceutics 2024 Mar 21;16(3):435. DOI: 10.1016/j.ijrobp.2024.04.012.
10	Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation. Cinat, D., Souza, A. L. D., Soto-Gamez, A., Jellema-de Bruin, A. L., Coppes, R. P. & Barazzuol, L., Jan-2024, In: Radiotherapy and Oncology. 190, 9 p., 110028. DOI: 10.1016/j.radonc.2023.110028
11	The Mayo Clinic Salivary Tissue-Organoid Biobanking: A Resource for Salivary Regeneration Research. Aalam, S. M. M., Varela, A. R., Khaderi, A., Mondesir, R. J., Mun, D.-G., Ding, A. Z., Lombaert, I. M. A., Coppes, R. P., Emperumal, C. P., Pandey, A., Janus, J. R. & Kannan, N., 27-Feb-2024, BioRxiv. DOI: 10.1101/2024.02.23.581761
12	Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Broghammer, F., Korovina, I., Gouda, M., Celotti, M., van Es, J., Lange, I., Brunner, C., Mircetic, J., Coppes, R. P., Gires, O., Dahl, A., Seifert, M. & Cordes, N., 21-Feb-2024, In: Molecular Cancer. 23, 25 p., 39. DOI: 10.1186/s12943-024-01954-8
13	Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state. Voshart, D. C., Oshima, T., Jiang, Y., van der Linden, G. P., Ainslie, A. P., Reali Nazario, L., van Buuren-Broek, F., Scholma, A. C., van Weering, H. R. J., Brouwer, N., Sewdihal, J., Brouwer, U., Coppes, R. P., Holtman, I. R., Eggen, B. J. L., Kooistra, S. M. & Barazzuol, L., 27-Feb-2024, 2 ed. 17 p. (Cell reports). DOI: 10.1016/j.celrep.2024.113764
14	Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS). Radstake, W. E., Parisi, A., Miranda, S., Gautam, K., Vermeesen, R., Rehnberg, E., Tabury, K., Coppes, R., van Goethem, M.-J., Brandenburg, S., Weber, U., Fournier, C., Durante, M., Baselet, B. & Baatout, S., 6-May-2024, In: Scientific Reports. 14, 1, 15 p., 10400. DOI: 10.1038/s41598-024-60912-y
15	Proton therapy induces a local microglial neuroimmune response. Voshart, D. C., Klaver, M., Jiang, Y., van Weering, H. R. J., van Buuren-Broek, F., van der Linden, G. P., Cinat, D., Kiewiet, H. H., Malimban, J., Vazquez-Matias, D. A., Reali Nazario, L., Scholma, A. C., Sewdihal, J., van Goethem, M.-J., van Luijk, P., Coppes, R. P. & Barazzuol, L., Apr-2024, In: Radiotherapy and Oncology. 193, 8 p., 110117. 10.1016/j.radonc.2024.110117
16	Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation. Soto-Gamez, A. A., van Es, M., Hageman, E., Serna-Salas, S. A., Moshage, H., Demaria, M., Pringle, S. & Coppes, R. P., Jan-2024, In: Radiotherapy and Oncology. 190, 109984. DOI: 10.1016/j.radonc.2023.109984
17	Clinical research for global needs of radiation oncology. Baumann, M., Bacchus, C., Aznar, M. C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., Krause, M., Lartigau, E. F., Lee, A. W. M., Löck, S., Offersen, B. V., Thwaites, D. I., van der Heide, U. A., Valentini, V. & Overgaard, J., Jan-2024, In: Radiotherapy and Oncology. 190, 5 p. DOI: 110076. 10.1016/j.radonc.2023.110076
18	"Derepression of transposable elements enhances interferon beta signaling and stem/progenitor cell activity after proton irradiation. 2. Cinat D, van der Wal R, Baanstra M, Soto-Gamez A, Jellema-de Bruin AL, van Goethem MJ, van Vugt MATM, Barazzuol L, Coppes RP. bioRxiv 2024.02.14.580306; doi: https://doi.org/10.1101/2024.02.14.580306."

Stefan Both

1	Toward Closing the Loop in Image-to-Image Conversion in Radiotherapy: A Quality Control Tool to Predict Synthetic Computed Tomography Hounsfield Unit Accuracy Zaffino, P., Raggio, C. B., Thummerer, A., Marmitt, G. G., Langendijk, J. A., Procopio, A., Cosentino, C., Seco, J., Knopf, A. C., Both, S. & Spadea, M. F., 10-Dec-2024, In: Journal of Imaging. 10, 12, 11 p., 316.
2	Target coverage and organs at risk dose in hypofractionated salvage radiotherapy after prostatectomy Staal, F. H. E., Janssen, J., Krishnapillai, S., Langendijk, J. A., Both, S., Brouwer, C. L. & Aluwini, S., Jul-2024, In: Physics and imaging in radiation oncology. 31, 7 p., 100600.
3	RayStation/GATE Monte Carlo simulation framework for verification of proton therapy based on the12N imaging Ahmadi Ganjeh, Z., Zapien-Campos, B., Traneus, E., Both, S. & Dendooven, P., 27-Sept-2024, In: Physics in Medicine and Biology. 69, 19, 15 p., 195007.
4	Proton PBS Planning Techniques, Robustness Evaluation, and OAR Sparing for the Whole-Brain Part of Craniospinal Axis Irradiation Matysiak, W. P., Landeweerd, M. C., Bannink, A., van der Weide, H. L., Brouwer, C. L., Langendijk, J. A., Both, S. & Maduro, J. H., Mar-2024, In: Cancers. 16, 5, 22 p., 892.
5	PET/CT based transformer model for multi-outcome prediction in oropharyngeal cancer Ma, B., Guo, J., De Biase, A., van Dijk, L. V., van Ooijen, P. M. A., Langendijk, J. A., Both, S. & Sijtsema, N. M., Aug-2024, In: Radiotherapy and Oncology. 197, 7 p., 110368.
6	Pelvic lymph node motion during cone-beam computed tomography guided stereotactic radiotherapy Janssen, J., Staal, F. H. E., Langendijk, J. A., Both, S., Brouwer, C. L. & Aluwini, S., Jul-2024, In: Clinical and Translational Radiation Oncology. 47, 6 p., 100794.
7	Optimal timing of re-planning for head and neck adaptive radiotherapy Gan, Y., Langendijk, J. A., Oldehinkel, E., Lin, Z., Both, S. & Brouwer, C. L., May-2024, In: Radiotherapy and Oncology. 194, 7 p., 110145.
8	Measurement of the12C(p,n)12N reaction cross section below 150 MeV Zapien Campos, B., Ahmadi Ganjeh, Z., Both, S. & Dendooven, P., 7-Apr-2024, In: Physics in Medicine and Biology. 69, 7, 20 p., 075025.
9	Magnetic Design of a Compact GaToroid for Very High Energy Electron and Pre-Clinical Hadron Beams Bottura, L., Haziot, A., Latina, A., Both, S., Gerbershagen, A., Butler, C., Dosanjh, M., Leadley, S. & Robertson, C., 1-Aug-2024, In: IEEE Transactions on Applied Superconductivity. 34, 5, 5 p., 4403005.
10	Feasibility of Monte Carlo dropout-based uncertainty maps to evaluate deep learning-based synthetic CTs for adaptive proton therapy Galapon, A., Thummerer, A., Langendijk, J. A., Wagenaar, D. & Both, S., 2024, In: Medical Physics. 51, 4, p. 2499-2509 11 p.
11	Deep learning-based outcome prediction using PET/CT and automatically predicted probability maps of primary tumor in patients with oropharyngeal cancer De Biase, A., Ma, B., Guo, J., van Dijk, L. V., Langendijk, J. A., Both, S., van Ooijen, P. M. A. & Sijtsema, N. M., Feb-2024, In: Computer Methods and Programs in Biomedicine. 244, 10 p., 107939.
12	Clinical implementation of deep learning robust IMPT planning in oropharyngeal cancer patients: A blinded clinical study van Bruggen, I. G., van Dijk, M., Brinkman-Akker, M. J., Löfman, F., Langendijk, J. A., Both, S. & Korevaar, E. W., Nov-2024, In: Radiotherapy and Oncology. 200, 7 p., 110522.
13	A probabilistic evaluation of the Dutch robustness and model-based selection protocols for Head-and-Neck IMPT: A multi-institutional study Rojo-Santiago, J., Habraken, S. J. M., Unipan, M., Both, S., Bosmans, G., Perkó, Z., Korevaar, E. & Hoogeman, M. S., Oct-2024, In: Radiotherapy and Oncology. 199, 9 p., 110441.
14	A planning study of proton therapy dose escalation for non-small cell lung cancer Hessels, A. C., Visser, S., Both, S., Korevaar, E. W., Langendijk, J. A. & Wijsman, R., Jul-2024, In: Physics and imaging in radiation oncology. 31, 5 p., 100616.